Fexostad 180 Mechanism of Action

Pharmacology: Pharmacodynamics: Fexofenadine hydrochloride is an antihistamine with selective peripheral H1-receptor antagonist activity. Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects. No sedative or other central nervous system effects were observed.
Pharmacokinetics: Fexofenadine is rapidly absorbed after oral administration with peak plasma concentrations being reached in 2 to 3 hours. It is about 60 to 70% bound to plasma proteins. About 5% of the total dose is metabolised, mostly by the intestinal mucosa, with only 0.5 to 1.5% of the dose undergoing hepatic biotransformation by the cytochrome P450 system. Elimination half­-life of about 14 hours has been reported although this may be prolonged in patients with renal impairment. Excretion is mainly in the faeces with only 10% being present in the urine. Fexofenadine does not appear to cross the blood-brain barrier.
Fexofenadine is a metabolite of terfenadine and as such has been detected in breast milk after the administration of terfenadine.